L-carnitine has a protective effect on the colonic mucosa during abdominopelvic radiotherapy in rats
Acta cir. bras
; 31(9): 615-620, Sept. 2016. tab, graf
Article
en En
| LILACS
| ID: lil-795991
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT PURPOSE:
To evaluate histopathologically the radioprotective effect of L-carnitine on the colonic mucosa in rats undergoing abdominopelvic irradiation.METHODS:
Thirty-two rats were randomly assigned to four experimental groups intraperitoneal administration of normal saline (group 1) or L-carnitine (300 mL/kg; group 2), followed in groups 3 and 4, respectively, by one dose of abdominopelvic radiation (20 Gy) 30 min later. Rats were sacrificed 5 days after radiation, and their descending colons were resected for histopathological evaluation of the presence and severity of damage.RESULTS:
Average damage scores did not differ significantly between groups 1 and 2 (0.13 ± 0.35 and 0.25 ± 0.46, respectively); the group 3 score was highest (10.25 ± 0.71), and the group 4 score (3.63 ± 1.41) was significantly lower than that of group 3 (both p = 0.0001). Pre-radiation L-carnitine administration significantly reduced mucosal thinning, crypt distortion, reactive atypia, inflammation, cryptitis, and reactive lymph-node hyperplasia (all p < 0.01).CONCLUSIONS:
L-carnitine had a radioprotective effect on rat colonic mucosa. L-carnitine use should be explored for patients with gastrointestinal cancer, who have reduced serum L-carnitine levels.Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Traumatismos Experimentales por Radiación
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Protectores contra Radiación
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Carnitina
/
Colitis
/
Mucosa Intestinal
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2016
Tipo del documento:
Article