Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing
Acta cir. bras
;
31(9): 586-596, Sept. 2016. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-795992
ABSTRACT
ABSTRACT PURPOSE:
To evaluate the contribution of L-arginine oral or topical rout of administration in the surgical wound healing process.METHODS:
L-arginine was orally or topically administrated to mice after a laparotomy model procedure. The wounds were analyzed to evaluate the granulation tissue by HE analysis, collagen deposition, iNOS and cytokines production by immunochemisyry on wound progress. Mice used in this model were healthy, immunosupressed or diabetic and all of them were treated with different concentration of L-arginine and rout of administration.RESULTS:
Suggested that groups treated with L-arginine orally or topically improved wound repair when compared with non-treatad mice. L- arginine treatment stimulated TGF-β and restricted NO production leading to a mild Th1 response and collagen deposition in injured area, when it was orally administrated. Topical administration decreased IL-8 and CCR1 expression by wound cells but did not interfere with TNF-α and IL-10 production, ratifying the decrease of inflammatory response, the oral administration however, presented a higher iNOS and TGF-β expression then. L-arginine treatment also improved the improved the wound healing in immunosupressed or diabetic mice.CONCLUSION:
L-arginine administrated orally or topically can be considered an important factor in the recuperation of tissues.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Arginina
/
Cicatrización de Heridas
/
Citocinas
/
Factor de Crecimiento Transformador beta
/
Óxido Nítrico Sintasa de Tipo II
/
Herida Quirúrgica
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de Brasília/BR
Similares
MEDLINE
...
LILACS
LIS