Metformina asociada a insulinoterapia en pacientes diabéticos tipo 1 / Metformin associated with insulin therapy in type 1 diabetic patients
Rev. chil. endocrinol. diabetes
; 8(2): 57-62, abr. 2015. tab, graf
Article
en Es
| LILACS
| ID: lil-797209
Biblioteca responsable:
CL1.1
ABSTRACT
In patients with diabetes type 1 (T1D) glycemic control remains suboptimal, despite the availability of new insulin analogues and continuous infusion systems. Metformin may be a complementary therapy regarding to intensified insulin therapy since a significant percentage of T1D have insulin resistance (IR). Objective:
To analyze the clinical, anthropometric and metabolic effects of the combination of metformin to insulin therapy in T1D patients. Subjects andMethod:
34 T1D patients, 15 men and 19 women, mean age 41 years (range 20-64) metformin 850 mg / day was associated for 6 months (group 1) and retrospectively evaluated 18 T1D, 9 men and 9 women, age average 34 years (range 17-58), who received metformin for 36 months (group 2). It was recorded before and after treatment with metformin nutritional status, waist circumference, index waist / hip, glucose fasting, glycosylated hemoglobin (HbA1c), HDL cholesterol, triglycerides, systolic and diastolic blood pressure (BP), glucose uptake (UG) and insulin dose (U/kg). Statistical analyses. Clinical and biochemical parameters were expressed as median, range or percentage (percent). For the statistical significance were used chi2and Fisher exact and Mann Whitney test; and was established as significant at p <0.05.Results:
In group 1 significantly decreased waist circumference in men and women and improved fasting glucose, HbA1c, systolic blood pressure and triglycerides. In group 2, waist circumference and systolic blood pressure was also reduced.Conclusion:
In T1D patients with clinical signs of IR the association of metformin to insulin therapy may be useful.Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Diabetes Mellitus Tipo 1
/
Hipoglucemiantes
/
Insulina
/
Metformina
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
Es
Revista:
Rev. chil. endocrinol. diabetes
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2015
Tipo del documento:
Article