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Paraoxonase 1 (PON1) Q192R genotypes and their interaction with smoking strongly increase atherogenicity and the Framingham risk score
Souza-Nogueira, Andre de; Camargo, Alissana Ester; Remondi, Felipe Assan; Paoliello, Monica Maria Bastos; Richter, Rebecca J; Furlong, Clement E; Barbosa, Decio Sabbatini; Maes, Michael; Moreira, Estefania Gastaldello.
  • Souza-Nogueira, Andre de; Universidade Estadual de Londrina. Londrina. BR
  • Camargo, Alissana Ester; Universidade Estadual de Londrina. Londrina. BR
  • Remondi, Felipe Assan; Universidade Estadual de Londrina. Londrina. BR
  • Paoliello, Monica Maria Bastos; Universidade Estadual de Londrina. Londrina. BR
  • Richter, Rebecca J; Universidade Estadual de Londrina. Londrina. BR
  • Furlong, Clement E; Universidade Estadual de Londrina. Londrina. BR
  • Barbosa, Decio Sabbatini; Universidade Estadual de Londrina. Londrina. BR
  • Maes, Michael; Universidade Estadual de Londrina. Londrina. BR
  • Moreira, Estefania Gastaldello; Universidade Estadual de Londrina. Londrina. BR
Arch. endocrinol. metab. (Online) ; 60(5): 426-435, Oct. 2016. tab, graf
Artículo en Inglés | LILACS | ID: lil-798175
ABSTRACT
ABSTRACT Objective Paraoxonase 1 (PON1) polymorphisms are associated with an increased susceptibility to cardiovascular disease. PON1 Q192R polymorphism (rs662) partially determine PON1 hydrolytic activity and protect against oxidation of LDL and HDL. This study aimed to delineate the association of PON1 status (functional 192 genotype and plasma activity levels) and atherogenicity in urbans residents aged 40 years or more. Materials and methods Anthropometric data, lipid profiles, the atherogenic index of the plasma (AIP) and Framingham score risk were measured. Three kinetic assays were conducted to assay PON1 status using phenylacetate and 4-(chloromethyl)phenyl acetate as substrates. Results Smoking per se did not significantly impact the AIP but the interaction PON1 genotype by smoking significantly increased the AIP. In subjects with the RR genotype smoking increased the AIP index from (estimated mean ± SEM) -0.038 ± 0.039 to 0.224 ± 0.094. The QR genotype increased the Framingham risk index by around 1.3 points. Smoking by RR genotype carriers significantly increased the Framingham risk score (17.23 ± 2.04) as compared to smoking (13.00 ± 1.06) and non-smoking (7.79 ± 0.70) by QQ+QR genotype carriers. The interaction RR genotype by smoking was a more important predictor (odds ratio = 7.90) of an increased Framingham risk score (> 20) than smoking per se (odds ratio = 2.73). The interaction smoking by RR genotype carriers significantly increased triglycerides and lowered HDL cholesterol. Conclusion Smoking per se has no (AIP) or a mild (Framingham risk score) effect on atherogenicity, while the interaction smoking by PON1 RR genotype has a clinically highly significant impact on atherogenicity.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Polimorfismo Genético / Medición de Riesgo / Arildialquilfosfatasa / Aterosclerosis / Genotipo Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio de prevalencia / Estudio pronóstico / Factores de riesgo Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: Endocrinologia / Metabolismo Año: 2016 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Estadual de Londrina/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Polimorfismo Genético / Medición de Riesgo / Arildialquilfosfatasa / Aterosclerosis / Genotipo Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio de prevalencia / Estudio pronóstico / Factores de riesgo Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: Endocrinologia / Metabolismo Año: 2016 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Estadual de Londrina/BR