Effect of tenoxican on inflammation and immune cellular function
Braz. j. med. biol. res
;
23(11): 1143-8, 1990. tab
Artículo
en Inglés
| LILACS
| ID: lil-91616
ABSTRACT
1. We have shown that nonsteroidal anti-inflammatory drugs are potent inhibitors of neutrophil activation. tenoxican is a new compound of the oxican family which has been shown to be effective for routine clinical use. 2. In the present study we examined the immune pharmacological effects of this compound on lymphocyte function by determining its efffect on the expression of IL-2 receptors, on monocyte function by looking at chemotaxis and IL-1 release and on release and on neutrophil function by evaluating the chemotactic response to a standard stimulus. 3. The data show that Tenoxican inhibits the neutrophil and monocyte functional chemotactic response in vitro, and to some extent in vivo for monocytes, but has no effect onthe expression of IL-2 receptors or IL-1 release. Tenoxicam inhibits the mobilization of neutrophils and monocytes to inflamatory sites, even thought this effect was not clearly demonstrable when cells were tested after oral use
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Índice:
LILACS (Américas)
Asunto principal:
Técnicas In Vitro
/
Linfocitos
/
Monocitos
/
Receptores de Interleucina-2
/
Piroxicam
/
Neutrófilos
Límite:
Humanos
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1990
Tipo del documento:
Artículo
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