Serum gama-glutamyl transpeptidase in chronic extrahepatic cholestasis
Braz. j. med. biol. res
; 23(6/7): 515-8, 1990.
Article
en En
| LILACS
| ID: lil-92195
Biblioteca responsable:
BR26.1
RESUMO
Studies in the literature have shown the inhibitory action action of bilirubin on serum gama-glutamyl transpeptidase (CGT) activity. In spite of this, CGT is a sensitive diagnostic indicator, comparable to alkaline phosphatase for the diagnosis of chronic extrahepatic cholestais (CEHC). To evaluate the relationship of bilirubin, alkaline phosphatase (AP) activity and GGT activity in CEHC we studied 30 patients with CEHC divided into two groups A, 14 male and female subjects with bilirubin levels of 10.1 to 44 mg/dl. Serum GGT activity was meaured by diluting serum samples 15 and 110. GGT values were equivalent in the two groups, there was no correlation between bilirubin and GGT (r = +0.179, P > 0.01) and there was a significant correlation between GGT and AP(r = +0.627, P < 0.01). The present results show that, if GGT inhibition by bilirubin did occur, this inhibitions was not sufficient to prevent the increase in serum GGT levels and that the sensitivity of GGT as a marker for CEHC is simular to that of alkaline phosphatase
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Índice:
LILACS
Asunto principal:
Colestasis Extrahepática
/
Bilirrubina
/
Fosfatasa Alcalina
/
Gamma-Glutamiltransferasa
Límite:
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1990
Tipo del documento:
Article
/
Congress and conference