Indomethacin affects the development of tolerance to ethanol-induced diuresis
Braz. j. med. biol. res
;
23(8): 701-3, 1990. tab, ilus
Artículo
en Inglés
| LILACS
| ID: lil-92279
ABSTRACT
The present study analyzes the effects of indomethacin on the development of tolerance to the diuretic effect of ethanol. Male Wistar rats were with ethanol (2gKg-1 day-1) over a period of 4 weeks and the effect of ethanol on diuresis was assessed weekly. A significant tolerance to the diuretic effect of ethanol was detected after 3 weeks of treatment. However, rats treatment simultaneously with ethanol plus indomethacin (5mg/Kg, ip,, on alternate days) showed no tolerance to ethanol even after 4 weeks of treatment. The fact that indonethacin prevented the development of tolerance to the diuretic effect of ethanol but no influence on diuresis per se suggests that prostaglandins play a significant role in the mechanisms of tolerance to ethanol
Buscar en Google
Índice:
LILACS (Américas)
Asunto principal:
Prostaglandinas
/
Indometacina
/
Diuresis
/
Etanol
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1990
Tipo del documento:
Artículo
/
Congreso y conferencia
Similares
MEDLINE
...
LILACS
LIS