Exogenous ganglioside stimulation of axonal regeneration after new transection and entubulation repair
Braz. j. med. biol. res
;
23(9): 823-6, 1990. ilus
Artículo
en Inglés
| LILACS
| ID: lil-92403
ABSTRACT
Adult male mice received sciatic nerve transection at the midthigh level and both nerve stumps were sutured into a polythylene tube (PT) to bridge a nerve gap of 4 mm. The tubes were implanted either empty, or filled with collagen alone or in combination with gangliosides (GM1, GD1a, GD1b, anhd GT1b). Following a survival time of 6 weeks, the PT with the regenerating nerve cables were processed for plastic embedding, and morphometric measurements were made on myelinated and unmyelinated axons. The data suggest that local application of exogenous gangliosides causes a stimulation of axonal sprouting in vivo with no effefct on the rate of axonal maturation
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Índice:
LILACS (Américas)
Asunto principal:
Nervio Ciático
/
Gangliósidos
/
Regeneración Nerviosa
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1990
Tipo del documento:
Artículo
/
Congreso y conferencia
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