Interaction between cholinergic and opiate receptors of the lateral hypothalamus in the control of renal excretion in rats
Braz. j. med. biol. res
;
23(6/7): 613-6, 1990. ilus
Artículo
en Inglés
| LILACS
| ID: lil-92458
ABSTRACT
The present study was carried out to investigate the participation and interaction between cholinergic and opiate receptors of the lateral hypothalamus (LH) in the regulation of Na+, K+ and water excretion. Malew Holtzman rats were implanted with chronic cerebral cannulas into the LH. Urine was collected over a period of 2h after injection of carbachol, FK-33824 + carbachol or naloxone + carbachol into the LH. Carbachol (8nmol) reduced urinary volume and increased Na + excretion. Previous injection of FK-333824(100ng) into the LH increased the antidiuretic effect of carbachol, but blocked the increase in Na+ excretion and decreased K+ excretion. Naloxone. Naloxone (10microng) produced no changes in the effect of carbacho9l on renal excretion. These data show an inhibitory effect of opiate receptors on the changes in urinary Na+ and K+ excretion that are induced by chronergic stimulation of the LH in rats, and a potentiating effect on antidiuresis
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Índice:
LILACS (Américas)
Asunto principal:
Carbacol
/
Receptores Colinérgicos
/
Receptores Opioides
/
Hipotálamo
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1990
Tipo del documento:
Artículo
/
Congreso y conferencia
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