Gd(-) Carapicuiba, a rare glucose-6 phosphate dehydrogenase variant associated with moderate enzyme deficiency and chronic hemolysis
Braz. j. med. biol. res
;
24(2): 133-9, 1991. tab
Artículo
en Inglés
| LILACS
| ID: lil-99446
ABSTRACT
A 27 year old Brazilian male of both Portuguese and Spanish origin presenting nonspherocytic chronic hemolytic anemia was found to have a rare glucose-6-phosphate dehydrogenase variant herein named Gd(-) Carapicuiba. The red blood cell enzyme variant is characterized by a moderate enzyme deficiency (47%), high Km for its substrates G6P and NADP, decreased activity against deamino-NADP, increased Ki for NADPH and decreased heat stability. The clinical signs of the patient are probably related to these properties of the enzyme variant
Buscar en Google
Índice:
LILACS (Américas)
Asunto principal:
Eritrocitos
/
Glucosafosfato Deshidrogenasa
/
Deficiencia de Glucosafosfato Deshidrogenasa
/
Anemia Hemolítica Congénita no Esferocítica
Tipo de estudio:
Factores de riesgo
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1991
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS