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Comparative evaluation of the antipyretic efficacy of ibuprofen and paracetamol.
Indian Pediatr ; 1990 Aug; 27(8): 803-6
Artículo en Inglés | IMSEAR | ID: sea-10069
ABSTRACT
An open multicentric trial was conducted on 175 patients to compare the antipyretic efficacy of ibuprofen (7 mg/kg) and paracetamol (8 mg/kg). Children between the age of 4 months and 12 years with fever were admitted to the study, 85 in the ibuprofen group and 90 in the paracetamol group. The axillary temperatures were recorded at half hourly intervals for 2 hours. The mean fall in temperature at 1, 1.5 and 2 hours was similar in both groups and the differences were not statistically significant (p greater than 0.05). At half hour, the fall in temperature (mean +/- SEM) for ibuprofen was 0.1975 +/- 0.0409 and for paracetamol was 0.3843 +/- 0.0490. This absolute difference of 0.19 degrees C was statistically significant (p less than 0.05). We conclude that ibuprofen has antipyretic activity comparable to that of paracetamol and that it could be a valuable alternative antipyretic in clinical practice. There is a need to repeat this trial with higher doses of ibuprofen, to establish a dose response of the drug, if any, and to find an optimally effective dose.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Femenino / Humanos / Masculino / Niño / Preescolar / Ibuprofeno / Fiebre / Lactante / Acetaminofén Tipo de estudio: Ensayo Clínico Controlado Idioma: Inglés Revista: Indian Pediatr Año: 1990 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Femenino / Humanos / Masculino / Niño / Preescolar / Ibuprofeno / Fiebre / Lactante / Acetaminofén Tipo de estudio: Ensayo Clínico Controlado Idioma: Inglés Revista: Indian Pediatr Año: 1990 Tipo del documento: Artículo