A double-blind placebo-controlled study on prophylactic use of cisapride on feed intolerance and gastric emptying in preterm neonates.
Indian Pediatr
;
2000 Aug; 37(8): 837-44
Artículo
en Inglés
| IMSEAR
| ID: sea-10149
ABSTRACT
OBJECTIVE:
To evaluate whether prophylactic use of cisapride will reduce the incidence of feed intolerance and gastro-esophageal reflux, and improve gastric emptying in early neonatal period in preterm babies.DESIGN:
Double blind randomized controlled trial.SETTING:
Hospital based.SUBJECTS:
Forty nine preterm babies between 29-34 weeks of gestation were administered either cisapride or placebo.METHODS:
Babies were enrolled in the study once they reached 30 ml/kg/day of enteral feeding or when 25% of total fluid intake was received through the enteral route. Those with sepsis, congenital malformations and on aminophylline were excluded. The subjects were randomized to receive either cisapride or placebo in a dose of 0.2 mg/kg/dose every 8 hourly for 14 days or till discharge. During the study period babies were observed for clinical signs of feed intolerance as judged by increase in abdominal girth, increased prefeed gastric residuals or vomiting. Gastro-esophageal reflux and gastric emptying time was assessed by Technetium phytate scan on day 7 +/- 1.RESULTS:
Feed intolerance was noticed in 59% of study and 41% of control population. No significant difference was noticed in the two groups in the total number of episodes of feed intolerance (1.54 +/- 2.4 vs 1.18 +/- 1.6). Nearly 50% of babies in each group had gastro-esophageal reflux. Gastric emptying time (mean (SD) and median) was found to be comparable (p = 0.70) in those on drug and placebo (58.1 (32.2 min) 48.8 min) vs (53.8 (34.6 min) 43.4 min).CONCLUSION:
Cisapride does not reduce the incidence of feed intolerance, gastro-esophageal reflux and does not improve gastric emptying in normal preterm neonates.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fármacos Gastrointestinales
/
Humanos
/
Recién Nacido
/
Recien Nacido Prematuro
/
Reflujo Gastroesofágico
/
Método Doble Ciego
/
Cisaprida
/
Hipersensibilidad a los Alimentos
/
Vaciamiento Gástrico
/
Enfermedades del Prematuro
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Inglés
Revista:
Indian Pediatr
Año:
2000
Tipo del documento:
Artículo
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