Effect of physostigmine and atropine on the single-trial passive avoidance response in rats.
Indian J Physiol Pharmacol
;
1982 Jul-Sep; 26(3): 201-6
Artículo
en Inglés
| IMSEAR
| ID: sea-106227
ABSTRACT
Rats received a single training trial on an inhibitory avoidance (passive avoidance) task and retention trials 24 hr (R-I) and 48 hr (R-II) later, in a special two-chambered apparatus, and the mean step-through latency was determined. The animals were given the drug, either pre-trial, pre-trial plus pre-retention, pre-retention or post-trial. Physostigmine (0.1 mg/kg, ip) and atropine (6.0 mg/kg, ip) had no effect on learning, but they adversely affected retention, particularly at 24 hr. The effect seems to involve central cholinergic mechanisms of retention.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fisostigmina
/
Ratas
/
Atropina
/
Reacción de Prevención
/
Animales
/
Memoria a Corto Plazo
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1982
Tipo del documento:
Artículo
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