Antidotal efficacy of pyridinium oximes and cholineacetyltransferase inhibitors against organophosphorus intoxication in rodents.
Indian J Physiol Pharmacol
;
2000 Jan; 44(1): 50-6
Artículo
en Inglés
| IMSEAR
| ID: sea-106293
ABSTRACT
In an attempt to develop effective antidote against organophosphorus intoxication, some new imidazole-pyridinium mono-oximes, long chain pyridinium mono-oximes and cholineacetyltransferase inhibitors were synthesised. These compounds were evaluated for their in vivo therapeutic protection and neuromuscular function studies in rodents. The results indicate that SPK-series oximes may be useful against sarin poisoning without any beneficial effect against VX (O-Ethyl S-2-NN-diisopropylaminoethyl methylphosphonofluoridate) intoxication. The cholineacetyltransferase (ChAT) inhibitors may not be of any help against any of the OP compounds studied in this study.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Compuestos Organofosforados
/
Compuestos Organotiofosforados
/
Oximas
/
Compuestos de Piridinio
/
Ratas
/
Sarín
/
Masculino
/
Colina O-Acetiltransferasa
/
Inhibidores de la Colinesterasa
/
Ratas Wistar
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
2000
Tipo del documento:
Artículo
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