Interaction of ciprofloxacin with diclofenac and paracetamol in relation to it's epileptogenic effect.
Indian J Physiol Pharmacol
;
1997 Apr; 41(2): 164-6
Artículo
en Inglés
| IMSEAR
| ID: sea-106377
ABSTRACT
A number of fluoroquinolones have shown convulsive potential. The effect of Ciprofloxacin was studied in electroconvulsive seizures in mice using the tonic extensor phase as end point and seizure threshold as observational parameter. Its interaction with diclofenac and paracetamol was also studied. It was found that Ciprofloxacin produced a significant epileptogenic effect. This was potentiated by diclofenac but paracetamol had no such effect. Though the exact mechanisms involved in this effect are conjectural, role of GABA inhibitory mechanisms is a possibility.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Convulsiones
/
Femenino
/
Masculino
/
Ciprofloxacina
/
Antiinflamatorios no Esteroideos
/
Diclofenaco
/
Analgésicos no Narcóticos
/
Sinergismo Farmacológico
/
Ácido gamma-Aminobutírico
/
Animales
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1997
Tipo del documento:
Artículo
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