Changes in glutathione, glutathione-linked enzymes and hexose monophosphate shunt enzymes in senile cataract.
Indian J Physiol Pharmacol
;
2003 Apr; 47(2): 191-6
Artículo
en Inglés
| IMSEAR
| ID: sea-106479
ABSTRACT
Changes in glucose-6-phosphate dehydrogenase (G-6-PD), glutathione reductase (GSH-R), reduced glutathione (GSH), glutathione peroxidase (GSH-PO), transketolase (TK) and transaldolase (TA) were studied in lens and red blood cells (RBCs) to understand the possible biochemical mechanisms responsible for the development of senile cataract. The activity of G-6-PD was increased in lens, though not so in erythrocytes during cataractogenesis. A marked decrease was observed in GSH level and GSH-R activity in the lens and RBCs of the cataractous group. The activity of GSH-PO was remarkably high in lens but not in the erythrocytes during the maturity of cataract. The activity of TK decreased gradually in both the lens and erythrocytes. The activity of TA decreased in erythrocytes but increased in the lens with maturation of cataract.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Vía de Pentosa Fosfato
/
Catarata
/
Anciano de 80 o más Años
/
Anciano
/
Humanos
/
Adulto
/
Glutatión
/
Glutatión Peroxidasa
/
Cristalino
/
Persona de Mediana Edad
Límite:
Aged80
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
2003
Tipo del documento:
Artículo
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