Involvement of nitric oxide (NO) in hypoglycaemic activity of tolbutamide.
Indian J Physiol Pharmacol
;
1998 Oct; 42(4): 551-4
Artículo
en Inglés
| IMSEAR
| ID: sea-106583
ABSTRACT
The study was conducted to find the involvement of Nitric Oxide (NO) using L-arginine, a NO precursor and NG-methyl L-arginine a nitric oxide synthase inhibitor on tolbutamide activity in normal rabbits. L-arginine (25-300 mg/kg, body weight, oral) produced transient and dose dependent hypoglycaemia. When combined with tolbutamide (40 mg/kg, oral) it produced early and prolonged action. The effect of tolbutamide was blocked by NG-methyl L-arginine (5 mg/kg, body weight, oral). The results confirm the involvement of NO in tolbutamide activity and the possibility of using L-arginine as a supplement to antidiabetic drugs in blood glucose control.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Arginina
/
Conejos
/
Tolbutamida
/
Glucemia
/
Femenino
/
Masculino
/
Hipoglucemia
/
Hipoglucemiantes
/
Animales
/
Óxido Nítrico
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1998
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS