Calcium modulatory properties of O,O-diphenyl O-N-cyclooctyl phosphoramidate [corrected] isolated from Ptychodiscus brevis in rat atria and smooth muscle.
Indian J Physiol Pharmacol
;
1997 Jul; 41(3): 257-62
Artículo
en Inglés
| IMSEAR
| ID: sea-106715
ABSTRACT
Calcium modulatory activity of a marine toxin has been studied employing in vitro preparations. The toxin induced contracture in rat diaphragm was not modified by denervation, d-tubocurarine and tetrodotoxin (TTX). In contrast, varying concentrations of calcium, EGTA and ryanodine inhibited the contracture significantly. The toxin produced a series of repeating contractions in vas deferens. Experiments with TTX, adrenoceptor blockers and other agents exclude a release of neuromediators or direct stimulation of post synaptic receptors to account for the rhythmic effect in vas deferens. The dependence of rhythmicity on external Ca2+ concentration and inhibiting effect of Mn2+, ryanodine and nifedipine indicate a direct activation of voltage-sensitive calcium channel. The toxin also evoked a similar pattern of response in paced atria mediated through Ca2+ influx.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Compuestos Organofosforados
/
Ratas
/
Conducto Deferente
/
Dinoflagelados
/
Masculino
/
Calcio
/
Función Atrial
/
Ratas Wistar
/
Cicloparafinas
/
Relación Dosis-Respuesta a Droga
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1997
Tipo del documento:
Artículo
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