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Calcium modulatory properties of O,O-diphenyl O-N-cyclooctyl phosphoramidate [corrected] isolated from Ptychodiscus brevis in rat atria and smooth muscle.
Indian J Physiol Pharmacol ; 1997 Jul; 41(3): 257-62
Artículo en Inglés | IMSEAR | ID: sea-106715
ABSTRACT
Calcium modulatory activity of a marine toxin has been studied employing in vitro preparations. The toxin induced contracture in rat diaphragm was not modified by denervation, d-tubocurarine and tetrodotoxin (TTX). In contrast, varying concentrations of calcium, EGTA and ryanodine inhibited the contracture significantly. The toxin produced a series of repeating contractions in vas deferens. Experiments with TTX, adrenoceptor blockers and other agents exclude a release of neuromediators or direct stimulation of post synaptic receptors to account for the rhythmic effect in vas deferens. The dependence of rhythmicity on external Ca2+ concentration and inhibiting effect of Mn2+, ryanodine and nifedipine indicate a direct activation of voltage-sensitive calcium channel. The toxin also evoked a similar pattern of response in paced atria mediated through Ca2+ influx.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Compuestos Organofosforados / Ratas / Conducto Deferente / Dinoflagelados / Masculino / Calcio / Función Atrial / Ratas Wistar / Cicloparafinas / Relación Dosis-Respuesta a Droga Idioma: Inglés Revista: Indian J Physiol Pharmacol Año: 1997 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Compuestos Organofosforados / Ratas / Conducto Deferente / Dinoflagelados / Masculino / Calcio / Función Atrial / Ratas Wistar / Cicloparafinas / Relación Dosis-Respuesta a Droga Idioma: Inglés Revista: Indian J Physiol Pharmacol Año: 1997 Tipo del documento: Artículo