Abuse liability of buprenorphine--a study among experienced drug users.
Indian J Physiol Pharmacol
;
1998 Jan; 42(1): 95-100
Artículo
en Inglés
| IMSEAR
| ID: sea-106770
ABSTRACT
Six male post-detoxified opiate dependent subjects were evaluated for abuse liability of buprenorphine (0.6 mg), morphine (16 mg), pentazocine (30 mg) and distilled water (placebo) intramuscular injection in a single blind cross-over random order. Subjective states, drug discrimination, drug linking, sedation and euphoria were assessed at pre-injection, 30 min and 4 hrs post-injection. Buprenorphine caused significant euphoria and was identified as heroin. On all parameters, buprenorphine resembled morphine rather than pentazocine and placebo. The data suggest that abuse liability of buprenorphine is similar to morphine i.e. moderate rather than low.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Buprenorfina
/
Humanos
/
Masculino
/
Niño
/
Encuestas y Cuestionarios
/
Adolescente
/
Adulto
/
Trastornos Relacionados con Sustancias
/
Euforia
/
Dependencia de Heroína
Tipo de estudio:
Ensayo Clínico Controlado
/
Investigación cualitativa
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1998
Tipo del documento:
Artículo
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