A study on withdrawal related haemodynamic response in chronic propranolol treated conscious rats.
Indian J Physiol Pharmacol
;
1993 Jul; 37(3): 235-7
Artículo
en Inglés
| IMSEAR
| ID: sea-106800
ABSTRACT
Single dose of propranolol hydrochloride (5 mg/kg, i.p.) caused significant fall in heart rate (HR) but not in systolic blood pressure (SBP) in normotensive conscious rats. Multiple doses of propranolol (5 mg/kg, i.p., twice-a-day for 5 wk) caused significant fall in both HR and SBP at 2 wk and 4 wk in normotensive conscious rats. Sudden withdrawal of propranolol at 5 wk caused a significant blood pressure upswing and tachycardia between 12-24 h followed by normalization of both blood pressure and heart rate. The study documents a possible model of rebound hypertension in normotensive conscious rats.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Propranolol
/
Ratas
/
Síndrome de Abstinencia a Sustancias
/
Taquicardia
/
Presión Sanguínea
/
Masculino
/
Ratas Wistar
/
Frecuencia Cardíaca
/
Hipertensión
/
Animales
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1993
Tipo del documento:
Artículo
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