Local anaesthetic activity of some new substituted acylamides II.
Indian J Physiol Pharmacol
;
1975 Apr-Jun; 19(2): 76-80
Artículo
en Inglés
| IMSEAR
| ID: sea-106844
ABSTRACT
Six new substituted acylamides, chemically related to lignocaine were studied for local anaesthetic activity and toxicity in mice, frogs and guinea pigs. Only one of these compounds, w-pyrrolidino 2, 3, 5, 6 tetramethyl acetanilide was found to possess potency comparable to lignocaine with a slightly higher therapeutic index. Study of the S.A.R. of this group indicated that by removal of two methyl groups at position 3 and 5 in the above compound, a local anaesthetic with greater potency than lignocaine may be obtained. Further exploration of the potentialities of a compound having pyrrolidine group as a part of basic side chain is indicated.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Anuros
/
Piperidinas
/
Propilaminas
/
Pirrolidinas
/
Relación Estructura-Actividad
/
Cola (estructura animal)
/
Morfolinas
/
Córnea
/
Dietilaminas
/
Dimetilaminas
Tipo de estudio:
Estudio diagnóstico
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1975
Tipo del documento:
Artículo
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