A study of some pharmacological actions of carbamazepine and sodium valproate.
Indian J Physiol Pharmacol
;
1984 Oct-Dec; 28(4): 315-8
Artículo
en Inglés
| IMSEAR
| ID: sea-106969
ABSTRACT
Carbamazepine (CA) and sodium valproate (SV) were studied for their actions of central nervous system and neuromuscular junction. CA and SV given ip neither possessed analgesic nor hypothermic activity in rats, nor did they alter the pentobarbitone sleeping time in mice. The drug had no effect on the frog rectus muscle nor did they alter its responses to acetylcholine. Both CA and SV produced a dose related decrease in indirectly evoked contractions of rat diaphragm and cat gastrocnemius muscle without much altering the directly evoked responses. This effect may be due to their local anaesthetic property, which was observed in infiltration test in guinea pigs.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Anuros
/
Conejos
/
Ratas
/
Sueño
/
Factores de Tiempo
/
Temperatura Corporal
/
Carbamazepina
/
Gatos
/
Sistema Nervioso Central
/
Ácido Valproico
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1984
Tipo del documento:
Artículo
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