Antagonism of apomorphine-induced cage climbing behaviour and methamphetamine stereotypy by fenfluramine in mice.
Indian J Physiol Pharmacol
;
1984 Oct-Dec; 28(4): 326-30
Artículo
en Inglés
| IMSEAR
| ID: sea-107020
ABSTRACT
Pretreatment with fenfluramine (5 and 10 mg/kg, ip) in doses which induced head twitches was found to antagonize apomorphine-induced cage climbing behaviour and methamphetamine stereotypy in mice. Since fenfluramine (5 and 10 mg/kg) did not induce catalepsy it indicates that fenfluramine lacks postsynaptic striatal and mesolimbic dopamine receptor blocking activity and it is possible that the fenfluramine-induced enhancement of central 5-hydroxytryptamine neuronal transmission may be responsible for its antagonistic effect on apomorphine-induced climbing behaviour and methamphetamine stereotypy.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Conducta Estereotipada
/
Humanos
/
Masculino
/
Apomorfina
/
Catalepsia
/
Fenfluramina
/
Animales
/
Metanfetamina
/
Ratones
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1984
Tipo del documento:
Artículo
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