Effect of L-histidine pretreatment on methamphetamine induced sterotyped behaviour in rats.
Indian J Physiol Pharmacol
;
1979 Oct-Dec; 23(4): 291-6
Artículo
en Inglés
| IMSEAR
| ID: sea-107114
ABSTRACT
Pretreatment with L-histidine precursor of histamine was found to delay the onset, shorten the duration and decrease the intensity of stereotyped behaviour induced by methamphetamine while chlorcylizine a H1 receptor blocker was found not only to potentiate methamphetamine induced sterotyped behaviour but also to block the inhibitory effect of L-histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Piperazinas
/
Ratas
/
Conducta Estereotipada
/
Factores de Tiempo
/
Conducta
/
Humanos
/
Masculino
/
Relación Dosis-Respuesta a Droga
/
Interacciones Farmacológicas
/
Histidina
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1979
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS