Steroidogenic inhibition in testicular tissue of formaldehyde exposed rats.
Indian J Physiol Pharmacol
;
1992 Jul; 36(3): 162-8
Artículo
en Inglés
| IMSEAR
| ID: sea-107178
ABSTRACT
Three groups of rats (n = 10) were subjected to intraperitoneal treatment of formaldehyde daily at doses of 5, 10 and 15 mg/kg body weight over a period of 30 days. Gradual diminution in body and testicular weight was observed in all treated groups. Leyding cell impairement was conspicuous in those given doses of 10 and 15 mg/kg. Inhibition of 3 beta-delta 5-hydroxy steroid dehydrogenase and accumulation of sudanophillic materials in testicular tissue of formaldehyde treated rats was recorded histochemically. Significant decline of serum testosterone was also observed in the same groups. Structural and functional impairement of Leydig cells after formaldehyde treatment caused steroidogenic inhibition.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Tamaño de los Órganos
/
Ratas
/
Espermatogénesis
/
Testículo
/
Testosterona
/
Peso Corporal
/
Masculino
/
Formaldehído
/
Hidroxiesteroide Deshidrogenasas
/
Inyecciones Intraperitoneales
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1992
Tipo del documento:
Artículo
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