Antiulcer activity and the mechanism of action of magaldrate in gastric ulceration models of rat.
Indian J Physiol Pharmacol
;
2000 Jul; 44(3): 350-4
Artículo
en Inglés
| IMSEAR
| ID: sea-107319
ABSTRACT
The present study was undertaken to investigate the mechanism of cytoprotective effects of magaldrate in aspirin plus pylorus-ligation model and ethanol-induced gastric ulcer model in rats. Magaldrate (60 mg/kg, p.o.) produced a significant reduction in the ulcer index and significant increase in mucus content in ethanol-induced gastric ulceration in rats. In aspirin plus pylorus-ligation model magaldrate produced significant decrease in ulcer index, total acidity and protein content (PR). It did not produce any significant change in volume of gastric secretion. However, it produced significant increase in total carbohydrate (TC) level but not in ratio between TC and proteins. It also produced a significant decrease in lipid peroxidation (as expressed by thiobarbituric acid reactive substance). Our data suggests the cytoprotective action of magaldrate on gastric mucosal cells which may be due to protection of gastric mucosa from lipid peroxidation.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Úlcera Gástrica
/
Femenino
/
Masculino
/
Peroxidación de Lípido
/
Etanol
/
Hidróxido de Aluminio
/
Mucosa Gástrica
/
Animales
/
Hidróxido de Magnesio
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
2000
Tipo del documento:
Artículo
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