Effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline.
Indian J Physiol Pharmacol
;
1993 Oct; 37(4): 303-7
Artículo
en Inglés
| IMSEAR
| ID: sea-107343
ABSTRACT
In a single dose crossover study, the effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline was investigated. Compared to fasting subjects, carbohydrate and fat rich diet caused an enhancement of absorption half life and a lower Cmax with a delayed tmax and elimination of the bronchodilator. Protein coadministration decreased AUCO-OC of the drug without significantly altering its absorption or elimination kinetics.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Teofilina
/
Femenino
/
Humanos
/
Masculino
/
Carbohidratos de la Dieta
/
Grasas de la Dieta
/
Proteínas en la Dieta
/
Ayuno
/
Adulto
/
Preparaciones de Acción Retardada
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1993
Tipo del documento:
Artículo
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