Interaction of calcium channel blockers (CCBs) with histamine and 5-hydroxytryptamine in aorta from normal and diseased rats.
Indian J Physiol Pharmacol
;
1996 Apr; 40(2): 120-6
Artículo
en Inglés
| IMSEAR
| ID: sea-107442
ABSTRACT
The present study attempts to investigate the interaction of calcium channel blockers (CCBs) with histamine (H) and 5-hydroxytryptamine (5-HT) in rat isolated aortic strip preparations. In preparations obtained from rats chronically treated with various CCBs the contractile responses to H were completely blocked suggesting that this may be due to inhibition of the voltage-dependent channels and inositol 1,4,5-triphosphate induced release of calcium from intracellular stores. The decreased contractions of the aortic strip preparations with 5-HT obtained from rats chronically treated with various CCBs implies a decrease in 5-HT receptor density. DOCA-saline hypertensive rats chronically treated with various CCBs showed variable responses to H and 5-HT suggesting that these changes may be due to different isoforms of L-type calcium channels. In L-thyroxine-treated preparations or those simultaneously treated with L-thyroxine and CCBs the responses to H were abolished and those to 5-HT were partially blocked with decrease in maxima which could be secondary to the primary effect on the heart and to generalised reduced senstivity of the rat aorta.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Aorta Torácica
/
Ratas
/
Masculino
/
Bloqueadores de los Canales de Calcio
/
Histamina
/
Serotonina
/
Ratas Wistar
/
Desoxicorticosterona
/
Hipertensión
/
Hipertiroidismo
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1996
Tipo del documento:
Artículo
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