Failure to reduce experimental myocardial infarct size with ibuprofen pre-treatment in rats.
Indian J Physiol Pharmacol
;
1992 Apr; 36(2): 133-4
Artículo
en Inglés
| IMSEAR
| ID: sea-107448
ABSTRACT
The prophylactic role of ibuprofen in experimental myocardial infarction has not been reported. Twenty-four rats pre-treated with ibuprofen (30 mg/kg), po, for 21 days were subjected to myocardial infarction by administration of isoprenaline hydrochloride (85 mg/kg), sc, on two consecutive days. An equal number of rats were given saline to serve as control. Heart specimens were taken for macroscopic and microscopic examination after 1 day, 5 days, 12 days and 21 days, following myocardial infarction. Ibuprofen pre-treatment caused a significant increase in infarct size at all the intervals studied (P less than 0.01), indicating that ibuprofen exerted a harmful effect in increasing the size of experimental myocardial infarction.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Femenino
/
Masculino
/
Ibuprofeno
/
Corazón
/
Isoproterenol
/
Animales
/
Infarto del Miocardio
/
Miocardio
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1992
Tipo del documento:
Artículo
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