Effect of drugs influencing synthesis of prostaglandins on haloperidol-induced catalepsy in rats.
Indian J Physiol Pharmacol
;
1984 Jul-Sep; 28(3): 219-22
Artículo
en Inglés
| IMSEAR
| ID: sea-107462
ABSTRACT
Rats pretreated with prostaglandin synthesis stimulators, phenoxymethyl penicillin (2, 4 and 8 mg/kg, ip) and levamisole (2.5, 5 and 10 mg/kg, ip) showed a dose related potentiation of catalepsy after subthreshold doses of haloperidol (0.1 mg/kg, ip). Pretreatment with prostaglandin synthesis inhibitors paracetamol and indomethacin exhibited significant inhibition of catalepsy at lower doses (2.5, 6, 10 and 15 mg/kg, ip). However, this antagonism was paradoxically less at higher dose levels (20 and 30 mg/kg, ip). The data suggest neuromodulatory contribution of prostaglandins in neuroleptic-induced catalepsy.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Humanos
/
Masculino
/
Catalepsia
/
Prostaglandinas
/
Levamisol
/
Indometacina
/
Penicilina V
/
Haloperidol
/
Animales
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1984
Tipo del documento:
Artículo
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