Recombinant human erythropoietin in anemia of prematurity.
Indian Pediatr
;
1999 Jan; 36(1): 17-27
Artículo
en Inglés
| IMSEAR
| ID: sea-10758
ABSTRACT
OBJECTIVE:
To evaluate safety and efficacy of recombinant human erythropoietin (r-HuEPO)in reducing the need for red cell transfusions in anemia of prematurity.METHODS:
forty -two preterm infants (gestational age <32 weeks) were randomly assigned to a "treatment" group (r-HuEPO 400 units/kg every alternate day * 10 doses) or "no treatment" (control) group. All infants on enteral feeds received oral iron 3 mg/kg/day, graded up to 6 mg/kg/day.RESULTS:
Higher reticulocyte counts in week 2 and 3 and higher hemoglobin levels in week 4 were noted after treatment with r-HuEPO. Despite stumulated erythropoiesis, the frequency of transfusions could not be reduced with r-HuEPO therapy.Overall, Phlebotomy losses, frequency and volume of redcell transfusions were significantly more in neonates with birthweight <1000 grams compared with those with birthweight >1000 grams (p<0.05). Associated side effects of r-HuEPO such as neutropenia,sepsis, hypertension or increased risk of late death did not occur.CONCLUSION:
r-HuEPO therapy was safe without any side effects.Inability of r-HuEPO therapy to minimize red cell transfusions for anemia of prematurity may be explained by a relatively strict red-cell transfusion policy and the desired degree of treatment effect.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Reticulocitos
/
Seguridad
/
Peso al Nacer
/
Femenino
/
Humanos
/
Masculino
/
Hemoglobinas
/
Recién Nacido
/
Recien Nacido Prematuro
/
Administración Oral
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Indian Pediatr
Año:
1999
Tipo del documento:
Artículo
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