Effect of aspartate and glutamate on nociception, catalepsy and core temperature in rats.
Indian J Physiol Pharmacol
;
1997 Apr; 41(2): 123-8
Artículo
en Inglés
| IMSEAR
| ID: sea-107690
ABSTRACT
Effects of excitatory aminoacids (EAAs) aspartate (ASP) and glutamate (GLU) in a low (50 ng, i.c.) and high dose (20 micrograms, i.c.), were studied on nociception, catalepsy and rectal temperature in albino rats. Both ASP and GLU altered the tail flick reaction time to thermal stimulation in a dose dependent manner, increasing it with low doses and reduced with high doses. Naloxone (10 micrograms, ic) antagonized the anti-nociceptive effect of EAAs while ketamine (10 micrograms, ic)-a NMDA receptor antagonist antagonized the hyperalgesic effect. These EAAs also antagonized catalepsy induced by haloperidol, chlorpromazine, trifluoperazine and morphine. Both ASP and GLU produced a hyperthermic response in all animals, including those in which hypothermia was induced by reserpine. These EAAs produced a comparable central modulatory effects on nociception, catalepsy and core temperature.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Reserpina
/
Trifluoperazina
/
Temperatura Corporal
/
Nociceptores
/
Masculino
/
Catalepsia
/
Clorpromazina
/
Ácido Aspártico
/
Ácido Glutámico
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1997
Tipo del documento:
Artículo
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