Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats.
Indian J Physiol Pharmacol
;
1996 Apr; 40(2): 163-6
Artículo
en Inglés
| IMSEAR
| ID: sea-107694
ABSTRACT
Possible central serotonergic and histaminergic modulation of acute peripheral inflammation was investigated in rats, adopting the formaldehyde-induced acute pedal inflammation as an experimental model. Intracerebroventricular (icv) administration of central inhibitory neurotransmitter, serotonin and its precursor, 5-hydroxytryptophan (5-HTP) attenuated the oedema volume and exudate protein content alongwith augmentation in pain threshold. On the contrary, cyproheptadine, a 5-HT-receptor antagonist and selective serotonin synthesis inhibitor, parachlorophenylalanine (PCPA) produced oedema augmenting and pro-nociceptive effects besides elevating the protein content of the exudate. Centrally administered histamine attenuated pedal oedema, nociception as well as protein concentration in oedema fluid. Cimetidine, an H2 histaminergic receptor blocker did not produce any significant effect on inflammation.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Dolor
/
Ratas
/
Antagonistas de la Serotonina
/
Factores de Tiempo
/
Nociceptores
/
Masculino
/
Histamina
/
Serotonina
/
Agonistas de Receptores de Serotonina
/
Ratas Sprague-Dawley
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1996
Tipo del documento:
Artículo
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