Effect of para-chlorophenylalanine on male rats: histopathological and biochemical changes in the testes.
Indian J Physiol Pharmacol
;
1986 Jul-Sep; 30(3): 223-31
Artículo
en Inglés
| IMSEAR
| ID: sea-107708
ABSTRACT
Spermatogenically active testes of rat challenged by 100 mg/kg body weight of p- Chlorophenylalanine for 45 days displayed marked and drastic changes in the seminiferous epithelium. Degenerative changes followed by immense necrosis of germ cells lead to complete breakdown of seminiferous tubules. Leydig cells, however, remained unaffected histologically in the treated animals. Among the accessory sex organs, epididymis alone showed a marked decrease in its weight. A biochemical study in the drug treated rats revealed a significant accumulation of glycogen in the testes accompanied by increase in the activities of enzymes like the succinic dehydrogenase, glucose-6-phosphatase, ATP-ase and acid phosphatases. However, a marked decrease was noticed in the activities of enzymes like alkaline phosphatase, phosphohexose isomerase and lactate dehydrogenase. No significant change was found in the protein, DNA and RNA concentrations in the drug treated testes. The histological and biochemical changes induced in the testes by p-CPA suggest the deleterious effect of the drug on the seminiferous tubules of the testes.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Ratas Endogámicas
/
Succinato Deshidrogenasa
/
Testículo
/
Masculino
/
Fenclonina
/
Adenosina Trifosfatasas
/
Monoéster Fosfórico Hidrolasas
/
Glucosafosfato Deshidrogenasa
/
Glucosa-6-Fosfato Isomerasa
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1986
Tipo del documento:
Artículo
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