Effects of diltiazem on calcium ion translocation: a study on isolated frog rectus abdominis muscle.
Indian J Physiol Pharmacol
;
1995 Jan; 39(1): 83-5
Artículo
en Inglés
| IMSEAR
| ID: sea-107732
ABSTRACT
Diltiazem, a calcium channel blocker was studied to observe its effects on the acetylcholine contractile responses of isolated frog rectus abdominis muscle. This response was modified in a dual manner i.e., initial potentiation, followed by inhibition. Diltiazem may not have anticholinesterase like mechanism, as it potentiated the responses to both acetylcholine and succinylcholine. Rectus muscle preparation, incubated in calcium free frog Ringer, showed dose dependent inhibition of acetylcholine contractile responses by diltiazem. The study suggests that diltiazem inhibits calcium ion influx across receptor operated calcium channels and may also inhibit calcium ion release from intracellular structures.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Anuros
/
Succinilcolina
/
Diltiazem
/
Canales de Calcio
/
Acetilcolina
/
Calcio
/
Recto del Abdomen
/
Relación Dosis-Respuesta a Droga
/
Sinergismo Farmacológico
/
Animales
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1995
Tipo del documento:
Artículo
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