Immunopharmacological studies on Picrorhiza kurroa Royle-ex-Benth. Part III: Adrenergic mechanisms of anti-inflammatory action.
Indian J Physiol Pharmacol
;
1988 Apr-Jun; 32(2): 120-5
Artículo
en Inglés
| IMSEAR
| ID: sea-107766
ABSTRACT
Nature of adrenergic mechanisms contributing to anti-inflammatory effect of Picrorhiza kurroa suggested from earlier studies was explored in Wistar albino rats. Water soluble fraction of alcoholic extract of rhizomes (PK) potentiated castor oil-catharsis on oral administration but direct subplanter PK-injections failed to exhibit any local irritancy and oedema. Propranolol pretreatment counteracted while phentolamine enhanced anti-inflammatory effect of PK in carrageenin-induced inflammation. 6-hydroxy-dopamine pretreatment antagonised the said PK-effect and in such animals both ephedrine and isoprenaline augmented anti-inflammatory effect of PK, the former interaction being more conspicuous. PK-treatment of rats did not influence adrenaline uptake by lung slices in vitro. The results suggest that a non-neural augmentation of beta-adrenoceptor function or consequent cellular events mediates the anti-inflammatory effect of PK.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Ratas Endogámicas
/
Masculino
/
Extractos Vegetales
/
Receptores Adrenérgicos beta
/
Oxidopamina
/
Hidroxidopaminas
/
Animales
/
Medicina Ayurvédica
/
Antiinflamatorios
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1988
Tipo del documento:
Artículo
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