Effect of metronidazole on the hepatic mixed function oxygenases (cytochromes b5 and P-450) in Swiss mice.
Indian J Physiol Pharmacol
;
1985 Oct-Dec; 29(4): 250-4
Artículo
en Inglés
| IMSEAR
| ID: sea-107845
ABSTRACT
Effect of metronidazole (MNZ) treatment (oral and ip) on activities of cytochrome b5 and P-450 was studied in male, virgin and pregnant female mice. Activities of both the cytochromes increased in virgin mice treated with 2 mg (ip or PO, per mouse) but not in male and pregnant females. 30 mg dose (per mouse) was toxic in pregnant mice but increased the cytochromes activities in males and virgin females. HPLC analysis of liver MNZ levels showed that virgin females had higher MNZ content than male and pregnant females when treated with ip injection of MNZ (250 mg/kg).
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Masculino
/
Embarazo
/
Citocromos b5
/
Grupo Citocromo b
/
Sistema Enzimático del Citocromo P-450
/
Isoenzimas
/
Hígado
/
Animales
/
Metronidazol
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1985
Tipo del documento:
Artículo
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