Effect of (Ala8,13,18)-magainin II amide on human trophoblast cells in vitro.
Indian J Physiol Pharmacol
;
2005 Jan; 49(1): 27-38
Artículo
en Inglés
| IMSEAR
| ID: sea-107856
ABSTRACT
Magainins are cationic peptides with anti-bacterial and anti-tumor properties. The anti-nidatory function of a synthetic analogue of magainin, (Ala8,13,18)-magainin II amide, has earlier been reported, and it has been indicated that placental trophoblast cells could be a target of magainin resulting in its contragestational action. The aim of the present study was to examine the effect of (Ala8,13,18)-magainin II amide (100 ng/ml and 1000 ng/ml) on attachment efficiency, viability, differentiation in terms of hCG secretion and invasive function of isolated first trimester, human placental trophoblast cells grown on rat-tail collagen type-I matrix in primary cell culture. In the present experimental model, magainin was not found to affect human trophoblast cell functions in vitro.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Péptidos
/
Trofoblastos
/
Femenino
/
Humanos
/
Embarazo
/
Diferenciación Celular
/
Supervivencia Celular
/
Células Cultivadas
/
Péptidos Catiónicos Antimicrobianos
/
Amidas
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
2005
Tipo del documento:
Artículo
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