Studies on the toxic effects of streptolysin 'O': effect on the contractility of isolated and intact mammalian and amphibian heart.
Indian J Physiol Pharmacol
;
1976 Jul-Sep; 20(3): 164-7
Artículo
en Inglés
| IMSEAR
| ID: sea-107858
ABSTRACT
The effect of streptolysin O (a streptococcal exotoxin) on the myocardial contractility of isolated and intact mammalian and amphibian heart has been investigated. Streptolysin O caused marked reduction or complete cessation of myocardial contractility of mammalian and amphibian heart both in vivo and in vitro. The effect of submaximal doses of streptolysin O on isolated atria was reversible after repeated washings and the myocardial depressant effect of streptolysin O on isolated atria was reversible after repeated washings and the myocardial depressant effect of streptolysin O was not antagonised by atropine. These observations would suggest that streptolysin O is cardiotoxic and may be involved in the causation of myocardial failure associated with acute rheumatic fever in man.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Conejos
/
Ratas
/
Atropina
/
Estreptolisinas
/
Gatos
/
Función Atrial
/
Función Ventricular
/
Depresión Química
/
Perros
/
Cobayas
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1976
Tipo del documento:
Artículo
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