Neuro-cognitive functions in patients of major depression.
Indian J Physiol Pharmacol
;
2007 Jan-Mar; 51(1): 69-75
Artículo
en Inglés
| IMSEAR
| ID: sea-107862
ABSTRACT
Earlier studies have shown conflicting results regarding impairment of executive functions in patients of major depression. In the present study, subjects were divided into following groups-Group 1 (19 Males & 11 females, age 18-45 years) consisting of patients of major depression diagnosed on the basis of DSM IV criteria and Group 2 (20 Males & 10 females, age 18-45 years) consisting of healthy subjects who had been screened for any sub-psychiatric illness by standardized hindi version of Goldberg's General Health Questionnaire (G.H.Q.). All the Group 1 & Group 2 subjects were rated on Hamilton Rating Scale for Depression (HAM-D) and then administered Neuro-cognitive test battery consisting of Letter Cancellation test, Trail Making test 'A' & 'B', Ruff Figural Fluency test, Forward & Reverse Digit Span test for assessing following cognitive domains Attention span, visuo-motor scanning, short term memory and executive functions like working memory, information manipulation, set-shifting strategy analysis etc. Results showed significant impairment on all the studied neuro-cognitive parameters in Group 1 subjects as compared to Group 2 subjects, which demonstrate significant impairment of attention, visuomotor speed, immediate verbal memory, short-term retentive capacity and executive functions (strategic planning, attentional set shifting and working memory) in patients of major depression. It may probably be due to the disruption of dorso-lateral prefrontal cortex (dlpfc) and orbito-frontal networks in patients of major depression.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Escalas de Valoración Psiquiátrica
/
Femenino
/
Humanos
/
Masculino
/
Adolescente
/
Corteza Prefrontal
/
Trastornos del Conocimiento
/
Adulto
/
Manual Diagnóstico y Estadístico de los Trastornos Mentales
/
Trastorno Depresivo Mayor
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
2007
Tipo del documento:
Artículo
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