Morphine hyperthermia in rats: role of neurochemical substances in brain.
Indian J Physiol Pharmacol
;
1981 Jul-Sep; 25(3): 237-45
Artículo
en Inglés
| IMSEAR
| ID: sea-108032
ABSTRACT
Central neurochemical mechanism underlying the hyperthermic effect of morphine has been investigated in rats. 200 micrograms morphine hydrochloride, when administered through cerebroventricular route at different seasonal air temperature, caused a rise in rectal temperature of rats. This hyperthermia was not affected by prior administration of antiserotonergic (pCPA, 5.6-DHT) or anticatecholaminergic (PBZ, 6-OHDA) drugs, as well as by PGE synthetase inhibitor, indomethacin. Similarity, cholinergic muscarinic or nicotinic receptor blockers, such as atropine and pentolinium/ D-tubocurarine respectively, were ineffective to modify it. Whereas, the depletion of acetylcholine in brain by pretreating the animals with hemicholinium profoundly delayed the hyperthermia, suggesting a central cholinergic involvement in morphine induced hyperthermia in rats.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Parasimpatolíticos
/
Antagonistas de Prostaglandina
/
Ratas
/
Antagonistas de la Serotonina
/
Temperatura
/
Temperatura Corporal
/
Química Encefálica
/
Masculino
/
Catecolaminas
/
Inyecciones Intraventriculares
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1981
Tipo del documento:
Artículo
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