Hepatoprotective effect of Himoliv, a polyherbal formulation in rats.
Indian J Physiol Pharmacol
;
2003 Oct; 47(4): 435-40
Artículo
en Inglés
| IMSEAR
| ID: sea-108170
ABSTRACT
The effect of Himoliv (HV) was evaluated in carbon tetrachloride or paracetamol induced hepatotoxicity in rats. Liver necrosis was produced by administering single dose of either carbon tetrachloride (CCl4, 1 ml/kg, 50% v/v with olive oil, s.c.) or paracetamol (PC, 1 g/kg, p.o.). The liver damage was evidenced by elevated levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and serum alkaline phosphatase (ALP) and hepatic thiobarbituric acid reacting substances (TBARS) and superoxide dismutase (SOD). HV pretreatment (0.5 and 1.0 ml/kg, p.o.) significantly (P < 0.001) reduced CCl4 or PC-induced elevations of the levels of SGOT, SGPT, ALP and TBARS, while the reduced concentration of SOD due to CCl4 or PC was reversed. Silymarin (25 mg/ kg, p.o.), a known hepatoprotective drug showed similar results.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Plantas Medicinales
/
Aspartato Aminotransferasas
/
Ratas
/
Femenino
/
Masculino
/
Tetracloruro de Carbono
/
Ratas Wistar
/
Preparaciones de Plantas
/
Alanina Transaminasa
/
Fosfatasa Alcalina
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
2003
Tipo del documento:
Artículo
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