Spinal motoneuron excitability in iron deficiency anaemia.
Indian J Physiol Pharmacol
;
2005 Apr; 49(2): 193-8
Artículo
en Inglés
| IMSEAR
| ID: sea-108352
ABSTRACT
Decreased tissue oxygenation resulting from iron deficiency anaemia produces generalized weakness and fatigue. The precise physiological mechanism underlying this weakness is unknown and studies in this regard have been scarce. One possible underlying mechanism has been suggested to be reduction of spinal motoneuron excitability. F waves are low amplitude motor responses to nerve stimulation, produced by antidromic activation of the peripheral motor fibers, resulting in recurrent discharge of motoneurons. F waves have been established as an efficient tool to assess spinal motoneuron excitability. 15 patients of iron deficiency anaemia using inclusion criteria of hemoglobin level < 9 g/dL and serum ferritin < 15 microg/L were studied. 8 controls with hemoglobin levels > 12 g/ dL were also included. Bilateral median and common peroneal F wave studies were performed. F wave mean latency, chronodispersion, persistence and mean amplitude were studied. They were within the normal range and no significant differences between the patients and the controls were found. We conclude that spinal motoneuron excitability is not reduced in iron deficiency anaemia. A decreased tissue oxygenation leading to a change in the brain neurotransmitters may have a role to play.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Médula Espinal
/
Femenino
/
Humanos
/
Masculino
/
Estudios de Casos y Controles
/
Anemia Ferropénica
/
Adulto
/
Estimulación Eléctrica
/
Electromiografía
/
Neuronas Motoras
Tipo de estudio:
Estudio observacional
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS