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Effect of Septilin--a herbal preparation on pharmacokinetics of carbamazepine in rabbits.
Indian J Physiol Pharmacol ; 1998 Oct; 42(4): 527-32
Artículo en Inglés | IMSEAR | ID: sea-108499
ABSTRACT
The study was carried out in rabbits, to see the effects of Septilin, a herbal preparation on the single and multiple dose kinetics of carbamazepine. Single dose treatment of Septilin significantly decreased t 1/2a. t 1/2e. AUCo-alpha of carbamazepine. Steady state Cmax and AUC0-24 of carbamazepine were also reduced significantly in comparison to those of control rabbits after 7 days co-administration of Septilin. We conclude that Septilin decrease/hinder the absorption process of carbamazepine through an unknown mechanism.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Conejos / Masculino / Carbamazepina / Extractos Vegetales / Antiinflamatorios no Esteroideos / Interacciones Farmacológicas / Animales / Anticonvulsivantes Idioma: Inglés Revista: Indian J Physiol Pharmacol Año: 1998 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Conejos / Masculino / Carbamazepina / Extractos Vegetales / Antiinflamatorios no Esteroideos / Interacciones Farmacológicas / Animales / Anticonvulsivantes Idioma: Inglés Revista: Indian J Physiol Pharmacol Año: 1998 Tipo del documento: Artículo