Preliminary study of the intense sympathetic discharge induced centrally after lateral ventricular administration of whole venom of Dendroaspis polylepis.

ABSTRACT

Lateral ventricular administration of 100 microgram of Dendroaspis polylepis venom is cats consistently produced a marked rise in arterial blood pressure, heart rate dilatation of pupils and piloerection. This intense central sympathetic discharge occurred after a latent period of 11.7 +/- 0.72 min. Bilateral adrenelectomy abolished the sympathetic discharge showing that central release of catecholamines from the adrenal medulla may play an important role in elicting the cardiovascular response.