Restoration on tissue antioxidants by fenugreek seeds (Trigonella Foenum Graecum) in alloxan-diabetic rats.
Indian J Physiol Pharmacol
;
2001 Oct; 45(4): 408-20
Artículo
en Inglés
| IMSEAR
| ID: sea-108523
ABSTRACT
The influence of fenugreek seed powder supplementation in the diet on lipid peroxidation and antioxidant status was studied in normal and alloxan-diabetic rats. The protective effect of the aqueous extract of the seeds on the activity of calcium-dependent adenosinetriphosphatase (Ca2+ ATPase) in liver homogenate in the presence of Fe2+/ascorbate in vitro was also investigated. Normal and diabetic rats were provided with a diet supplemented with fenugreek seed powder for 30 days at a dosage of 2 g/kg body weight. The diabetic rats exhibited enhanced lipid peroxidation and increased susceptibility to oxidative stress associated with depletion of antioxidants in liver, kidney and pancreas. However, treatment with fenugreek seed powder normalised the alterations. In normal rats supplementation resulted in increased antioxidant status with reduction in peroxidation. Ca2+ ATPase activity in liver was protected by the aqueous extract to nearly 80% of the initial activity. The findings suggest that the soluble portion of the seeds could be responsible for the antioxidant property.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Superóxido Dismutasa
/
Peso Corporal
/
Masculino
/
Extractos Vegetales
/
Peroxidación de Lípido
/
Catalasa
/
Ratas Wistar
/
ATPasas Transportadoras de Calcio
/
Trigonella
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
2001
Tipo del documento:
Artículo
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