Serum phenytoin levels with different brands.
Indian J Physiol Pharmacol
;
1986 Apr-Jun; 30(2): 171-6
Artículo
en Inglés
| IMSEAR
| ID: sea-108540
ABSTRACT
Four brands of phenytoin were studied in 60 newly diagnosed epileptic patients randomly and equally placed in 4 groups. Serum phenytoin levels were estimated by EMIT and spectrophotometric methods both of which gave close values with good correlation (r = 0.985). Average serum levels and the incidence of remission achieved with the 4 brands varied within statistical scatter; thus these 4 brands manifested equivalent therapeutic efficacy. In 22 patients serum level was less than 5 micrograms/ml, in 9 of whom attacks remained uncontrolled. In 38 patients serum level exceeded 5 micrograms/ml in 2 of whom attacks were uncontrolled. In 44 out of 60 patients the 2 weeks serum levels were significantly higher (P less than 0.001 by paired t-test) than those after 3 months. In the remaining 16 patients the serum levels at 3 months were significantly higher than at 2 weeks levels (P less than 0.01).
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fenitoína
/
Espectrofotometría
/
Femenino
/
Humanos
/
Masculino
/
Disponibilidad Biológica
/
Distribución Aleatoria
/
Técnicas para Inmunoenzimas
/
Adulto
/
Epilepsia
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1986
Tipo del documento:
Artículo
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