Sedative action of some substituted benzylamides.
Indian J Physiol Pharmacol
;
1977 Jan-Mar; 21(1): 1-10
Artículo
en Inglés
| IMSEAR
| ID: sea-108557
ABSTRACT
Substituted benzylamide derivatives of amino acylamide (compound A,B,C, & D) were found to be less potent local anaesthetics than lignocaine and procaine. However, the four compounds exhibited sedation without ptosis and reduced spontaneous locomotor activity better than methaqualone. Compound A alone antagonised methylamphetamine induced hypermotor activity. The test compounds potentiated hexobarbitone induced hypnosis. Three compounds antagonised calcium induced stoppage of isolated heart of frog. Except compound C all caused a transitory fall of blood pressure in dog which was not blocked either by atropine or propranolol. These compounds showed neuromuscular blockade and possessed slight analgesic activity but were devoid of anticonvulsant and tranquillizing activity. LD 50 values were calculated to be 164.1 +/- 23.0, 229.1 +/- 51.0, 181.6 +/- 28.18 and 416+/-38.2 mg/kg for compounds A,B,C & D respectively.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Anuros
/
Conejos
/
Ratas
/
Compuestos de Bencilo
/
Presión Sanguínea
/
Femenino
/
Masculino
/
Depresión Química
/
Perros
/
Amidas
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1977
Tipo del documento:
Artículo
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