Possible mechanism of endosulfan-induced enhancement of memory acquisition and retention in mice.
Indian J Physiol Pharmacol
;
1994 Apr; 38(2): 138-40
Artículo
en Inglés
| IMSEAR
| ID: sea-108577
ABSTRACT
The effects of pre-training and post-training administration of endosulfan on retention of a step-down passive avoidance task was studied in mice. Endosulfan at doses of 1.0 mg/kg(ip) and 2.0 mg/kg(ip) enhanced memory acquisition and retention. This effect of endosulfan was possibly mediated by interaction with cholinergic neurotransmission, as scopolamine (0.5 mg/kg, ip) significantly antagonized the memory enhancing effects of endosulfan. Clonidine (0.05 mg/kg, ip) did not have any effect on enhancement of memory produced by endosulfan, thus indicating possibly no role of noradrenergic system.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Escopolamina
/
Reacción de Prevención
/
Masculino
/
Clonidina
/
Transmisión Sináptica
/
Relación Dosis-Respuesta a Droga
/
Interacciones Farmacológicas
/
Endosulfano
/
Inyecciones Intraperitoneales
/
Animales
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1994
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS