Effect of alpha-methyl-p-tyrosine on neuroleptic-induced catalepsy in rat.
Indian J Physiol Pharmacol
;
1983 Jul-Sep; 27(3): 241-4
Artículo
en Inglés
| IMSEAR
| ID: sea-108832
ABSTRACT
Pretreatment with alpha-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor, was found to increase the intensity of catalepsy induced by haloperidol, chlorpromazine and molindone. The drug probably decreases the synthesis of dopamine and makes less dopamine available for release and to compete with the neuroleptic for the postsynaptic striatal dopamine receptor sites with resultant potentiation of the neuroleptic-induced catalepsy.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Antipsicóticos
/
Humanos
/
Masculino
/
Dopamina
/
Catalepsia
/
Clorpromazina
/
Alfa-Metiltirosina
/
Sinergismo Farmacológico
/
Haloperidol
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1983
Tipo del documento:
Artículo
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